¿De dónde vienen las enfermedades autoinmunes?

Resumen del corpus

The article explores the origin of autoimmune diseases by suggesting that natural selection, acting over millennia, has preserved genetic variants that were advantageous in past environments (like those involving infectious diseases or specific lifestyles) but are now detrimental in modern conditions. This concept, termed 'antagonistic pleiotropy,' suggests that genes beneficial in the past may now increase the risk of autoimmune conditions as modern sanitation and infection control measures have changed the selective pressures. Evidence is drawn from genetic sequencing comparisons with ancient DNA and historical events like the Bronze Age and the Black Death.